![]() ![]() History of psychosis, presence of infection at the injection site, uncontrolled bleeding, or spinal canal obstruction that impairs CSF circulation, IV administration Drug Interactions of Concern to DentistryĮlimination half-life is increased by an increase in volume of distribution or a decrease in clearance, and vice versa. Insomnia, dry skin, constipation, arthralgia, myalgia, tremor Precautions and Contraindications ![]() Side Effects/Adverse Reactions Frequentĭizziness, nausea, somnolence, weakness, diarrhea, confusion, ataxia, headache, vomiting, gait disturbance, memory impairment, hypertonia OccasionalĪnorexia, visual disturbances, anxiety, urinary retention, speech disorder, aphasia, nystagmus, paresthesia, fever, hallucinations, nervousness, vertigo Rare May titrate to maximum of 19.2 mcg/day (0.8 mcg/hr). Indications and Dosages ▸ Pain Control Intrathecal Adults, Elderly. Excreted in urine as proteolytic degradation products. 50% bound to plasma proteins metabolized in multiple organs. Reduction of chronic pain in the body PharmacokineticsĮlimination Half-life: 4.6 hr after intrathecal administration. Therapeutic Effect: Blocks excitatory neurotransmitter release, reducing sensitivity to painful stimuli. In Mosby's Dental Drug Reference (Eleventh Edition), 2014 Drug Class:Ī synthetic peptide that selectively binds to and blocks N-type voltage-sensitive calcium channels located on afferent nerves in the spinal cord. ![]()
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